View source for 1vzh

[[Image:1vzh.gif|left|200px]]

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{{STRUCTURE_1vzh|  PDB=1vzh  |  SCENE=  }} 

'''STRUCTURE OF SUPEROXIDE REDUCTASE BOUND TO FERROCYANIDE AND ACTIVE SITE EXPANSION UPON X-RAY INDUCED PHOTOREDUCTION'''


==Overview==
Some sulfate-reducing and microaerophilic bacteria rely on the enzyme superoxide reductase (SOR) to eliminate the toxic superoxide anion radical (O2*-). SOR catalyses the one-electron reduction of O2*- to hydrogen peroxide at a nonheme ferrous iron center. The structures of Desulfoarculus baarsii SOR (mutant E47A) alone and in complex with ferrocyanide were solved to 1.15 and 1.7 A resolution, respectively. The latter structure, the first ever reported of a complex between ferrocyanide and a protein, reveals that this organo-metallic compound entirely plugs the SOR active site, coordinating the active iron through a bent cyano bridge. The subtle structural differences between the mixed-valence and the fully reduced SOR-ferrocyanide adducts were investigated by taking advantage of the photoelectrons induced by X-rays. The results reveal that photo-reduction from Fe(III) to Fe(II) of the iron center, a very rapid process under a powerful synchrotron beam, induces an expansion of the SOR active site.

==About this Structure==
1VZH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Desulfovibrio_baarsii Desulfovibrio baarsii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VZH OCA]. 

==Reference==
Structure of superoxide reductase bound to ferrocyanide and active site expansion upon X-ray-induced photo-reduction., Adam V, Royant A, Niviere V, Molina-Heredia FP, Bourgeois D, Structure. 2004 Sep;12(9):1729-40. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15341736 15341736]
[[Category: Desulfovibrio baarsii]]
[[Category: Single protein]]
[[Category: Superoxide reductase]]
[[Category: Adam, V.]]
[[Category: Bourgeois, D.]]
[[Category: Molina-Heredia, F P.]]
[[Category: Niviere, V.]]
[[Category: Royant, A.]]
[[Category: Dinuclear iron cluster]]
[[Category: Electron transport]]
[[Category: Ferrocyanide]]
[[Category: Microspectrophotometry]]
[[Category: Oxidoreductase]]
[[Category: Photoreduction]]
[[Category: Redox state]]
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