View source for 1aqz

[[Image:1aqz.gif|left|200px]]<br />
<applet load="1aqz" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1aqz, resolution 1.7&Aring;" />
'''CRYSTAL STRUCTURE OF A HIGHLY SPECIFIC ASPERGILLUS RIBOTOXIN, RESTRICTOCIN'''<br />

==Overview==
BACKGROUND: Restriction, a highly specific ribotoxin made by the fungus, Aspergillus restrictus, cleaves a single phosphodiester bond in the 28S, RNA of eukaryotic ribosomes, inhibiting protein synthesis. The sequence, around this cleavage site is a binding site for elongation factors, and is, conserved in all cytoplasmic ribosomes. The catalytic mechanism of, restrictocin and the reasons for its high substrate specificity are, unknown. No structure has been determined for any other member of the, Aspergillus ribotoxin family. RESULTS: The crystal structure of, restrictocin was determined at 2.1 A resolution by single isomorphous, replacement and anomalous scattering techniques, and refined to 1.7 A, resolution using synchrotron Laue data. The structural core of the, protein, in which a ... [[http://ispc.weizmann.ac.il/pmbin/getpm?8805570 (full description)]]

==About this Structure==
1AQZ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Aspergillus_restrictus Aspergillus restrictus]] with PO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AQZ OCA]]. 

==Reference==
Insights into specificity of cleavage and mechanism of cell entry from the crystal structure of the highly specific Aspergillus ribotoxin, restrictocin., Yang X, Moffat K, Structure. 1996 Jul 15;4(7):837-52. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8805570 8805570]
[[Category: Aspergillus restrictus]]
[[Category: Single protein]]
[[Category: Moffat, K.]]
[[Category: Yang, X.]]
[[Category: PO4]]
[[Category: cell-entry activity]]
[[Category: laue diffraction]]
[[Category: protein-rna specific interaction]]
[[Category: ribosome-inactivating protein]]
[[Category: ribotoxin]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 18:40:43 2007''