View source for 1xpc

[[Image:1xpc.gif|left|200px]]<br />
<applet load="1xpc" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1xpc, resolution 1.60&Aring;" />
'''HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 19'''<br />

==Overview==
A series of dihydrobenzoxathiin SERAMs with alkylated pyrrolidine side, chains or alkylated linkers was prepared. Minor modifications in the side, chain or linker resulted in significant effects on biological activity, especially in uterine tissue.

==Disease==
Known diseases associated with this structure: Atherosclerosis, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=133430 133430]], Breast cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=133430 133430]], Estrogen resistance OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=133430 133430]], HDL response to hormone replacement, augmented OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=133430 133430]], Migraine, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=133430 133430]], Myocardial infarction, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=133430 133430]]

==About this Structure==
1XPC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with AIT as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1XPC OCA]. 

==Reference==
Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers., Blizzard TA, Dininno F, Morgan JD 2nd, Chen HY, Wu JY, Kim S, Chan W, Birzin ET, Yang YT, Pai LY, Fitzgerald PM, Sharma N, Li Y, Zhang Z, Hayes EC, Dasilva CA, Tang W, Rohrer SP, Schaeffer JM, Hammond ML, Bioorg Med Chem Lett. 2005 Jan 3;15(1):107-13. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15582421 15582421]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Fitzgerald, P.M.D.]]
[[Category: Sharma, N.]]
[[Category: AIT]]
[[Category: antagonist]]
[[Category: er-alpha]]
[[Category: nuclear receptor]]
[[Category: transcription factor]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 20:09:16 2007''