View source for Sodium-hydrogen exchange regulatory factor

<StructureSection load='4q3h' size='340' side='right' caption='Human NHERF-1 second PDZ domain with CXCR2 peptide chimera (PDB cod [[4q3h]])' scene=''>


== Function ==

'''Sodium-hydrogen exchange regulatory factors''' (NHERF) or '''ezrin-radixin-moesin binding phosphoprotein-50''' or '''PDZ domain-containing protein''' or '''Na+/H+ exchange regulatory cofactor NHE-RF1''' or '''NHERF''' are multifunctional adaptor protein which plays a role in the assembly of signal transduction complexes, linking ion channels and receptors to the actin skeleton<ref>PMID:11141479</ref>. 
* '''NHERF-1''' is the major isoform present in the brain and it regulates the trans-cellular ion transport through the blood-brain barrier membrane<ref>PMID:26010555</ref>.  Ittransduces cyclic AMP signals that inhibit the sodium-hydrogen exchanger present at the surface of kidney and gut<ref>PMID:12586353</ref>. 


== Relevance ==

NHERF-1 inhibitors represent a potentially effective therapeutic approach to the treatment of hear failure<ref>PMID:12223070</ref>.  NHERF-1 has a vital role in kidney cell survival<ref>PMID:25680790</ref>.  NHERF are known to be involved in pathophysiologies of many brain diseases like epilepsy, Alzhheimer's disease, neuropathic pain and stroke.

== Structural highlights ==

NHERF interacts with ion transporters and receptors via its PDZ domains and with the merlin, ezrin, radixin and moesin proteins via its c-terminal.  The CXCR2 peptide binds the second PDZ domain hydrophobic cleft<ref>PMID:26010555</ref>.

== 3D Structures of sodium-hydrogen exchange regulatory factor ==
[[Sodium-hydrogen exchange regulatory factor 3D structures]]

== References ==
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</StructureSection>
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