View source for Bromodomain-containing protein

<StructureSection load='' size='350' side='right' caption='Human bromodomain-containing protein 4 bromodomain 1 complex with inhibitor and ethylene glycol (PDB code [[3p5o]])' scene='72/724778/Cv/1'>
== Function ==

'''Bromodomain-containing proteins''' (BRD) are active as histone acetyltransferase, chromatin remodeling and transcriptional mediation.  The bromodomain is a ca. 110 amino acid long sequence which recognizes acetylated lysine residues which are found in the C-terminal of histones<ref>PMID:11911891</ref>.
*'''BRD1''' is essential for normal brain development<ref>PMID:35941107</ref>.
*'''BRD2''' promotes spatial mixing and compartmentalisation of chromatin<ref>PMID:35410381</ref>. 
*'''BRD3''' and '''BRD4''' regulate skeletal myogenesis<ref>PMID:28733670</ref>.  For detalis on BRD3 see [[Human bromodomain containing protein 3]]
*'''BRD7''' promotes colorectal cancer by regulating the ubiquitin-proteasome-dependent stabilisation of c-Myc protein<ref>PMID:34109174</ref>. 

== Disease ==

Dysfunction of BRD is involved in cancer, inflammation, obesity and multiple sclerosis<ref>PMID:22722403</ref>.  BRD4 translocations are detected in NUT midline carcinoma and a variety of BRD4 inhibitors are clinically tested at the present<ref>PMID:18552174</ref>.

== Structural highlights ==

<scene name='72/724778/Cv/4'>BRD4 bromodomain 1 inhibitors bind to the acetyl-binding pocket</scene><ref>PMID:18552174</ref>. Water molecules are shown as red spheres.


== 3D Structures of bromodomain-containing protein ==
[[Bromodomain-containing protein 3D structures]]

</StructureSection>

== References ==
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