View source for 1sch

[[Image:1sch.gif|left|200px]]

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{{STRUCTURE_1sch|  PDB=1sch  |  SCENE=  }} 

'''PEANUT PEROXIDASE'''


==Overview==
BACKGROUND. Peroxidases catalyze a wide variety of peroxide-dependent oxidations. Based on sequence alignments, heme peroxidases have been divided into three classes. Crystal structures are available for peroxidases of classes I and II, but until now no structure has been determined for class III, the classical extracellular plant peroxidases. RESULTS. The crystal structure of peanut peroxidase has been solved to 2.7 A resolution. The helical fold is similar to that of known peroxidase structures. The 294-residue polypeptide chain is accompanied by a heme and two calcium ions, and there is some evidence of glycosylation. CONCLUSIONS. This is the first complete structure of a class III peroxidase and as such should serve as a model for other class III enzymes including the much-studied horseradish peroxidase. It may also aid in the interpretation of functional differences between the peroxidase classes. Ten helices conserved in class I and II peroxidases are also found in peanut peroxidase. Key residues of the heme environment and the location of two calcium ions are shared with class II peroxidases. Peanut peroxidase contains three unique helices, two of which contribute to the substrate access channel leading to the heme edge.

==About this Structure==
1SCH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Arachis_hypogaea Arachis hypogaea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SCH OCA]. 

==Reference==
The crystal structure of peanut peroxidase., Schuller DJ, Ban N, Huystee RB, McPherson A, Poulos TL, Structure. 1996 Mar 15;4(3):311-21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8805539 8805539]
[[Category: Arachis hypogaea]]
[[Category: Peroxidase]]
[[Category: Single protein]]
[[Category: Poulos, T L.]]
[[Category: Schuller, D J.]]
[[Category: Calcium binding]]
[[Category: Glycosylation]]
[[Category: Oxidoreductase]]
[[Category: Peroxidase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:32:38 2008''