View source for 1itf


==INTERFERON ALPHA-2A, NMR, 24 STRUCTURES==
<StructureSection load='1itf' size='340' side='right'caption='[[1itf]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1itf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The August 2010 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Interferons''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2010_8 10.2210/rcsb_pdb/mom_2010_8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ITF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ITF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1itf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1itf OCA], [https://pdbe.org/1itf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1itf RCSB], [https://www.ebi.ac.uk/pdbsum/1itf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1itf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IFNA2_HUMAN IFNA2_HUMAN] Produced by macrophages, IFN-alpha have antiviral activities.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/it/1itf_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1itf ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Interferon 3D structures|Interferon 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Interferons]]
[[Category: Large Structures]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Gsell B]]
[[Category: Klaus W]]
[[Category: Labhardt AM]]
[[Category: Senn H]]
[[Category: Wipf B]]