View source for 4jzc


==Angiopoietin-2 fibrinogen domain TAG mutant==
<StructureSection load='4jzc' size='340' side='right'caption='[[4jzc]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4jzc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JZC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JZC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jzc OCA], [https://pdbe.org/4jzc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jzc RCSB], [https://www.ebi.ac.uk/pdbsum/4jzc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jzc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ANGP2_HUMAN ANGP2_HUMAN] Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.<ref>PMID:9204896</ref> <ref>PMID:15284220</ref> <ref>PMID:19116766</ref> <ref>PMID:19223473</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Barton WA]]
[[Category: Dalton AC]]
[[Category: Goldgur Y]]
[[Category: Nikolov DB]]
[[Category: Seegar TCM]]
[[Category: Tzvetkova-Robev D]]
[[Category: Yu X]]