View source for 1ssl

[[Image:1ssl.gif|left|200px]]<br />
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'''Solution structure of the PSI domain from the Met receptor'''<br />

==Overview==
PSI domains are cysteine-rich modules found in extracellular fragments of, hundreds of signaling proteins, including plexins, semaphorins, integrins, and attractins. Here, we report the solution structure of the PSI domain, from the human Met receptor, a receptor tyrosine kinase critical for, proliferation, motility, and differentiation. The structure represents a, cysteine knot with short regions of secondary structure including a, three-stranded antiparallel beta-sheet and two alpha-helices. All eight, cysteines are involved in disulfide bonds with the pattern consistent with, that for the PSI domain from Sema4D. Comparison with the Sema4D structure, identifies a structurally conserved core comprising the N-terminal half of, the PSI domain. Interestingly, this part links adjacent SEMA and, immunoglobulin domains in the Sema4D structure, suggesting that the PSI, domain serves as a wedge between propeller and immunoglobulin domains and, is responsible for the correct positioning of the ligand-binding site of, the receptor.

==Disease==
Known diseases associated with this structure: Autism, suseptibility to, 9 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]], Hepatocellular carcinoma, childhood type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]], Renal cell carcinoma, papillary, familial and sporadic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]]

==About this Structure==
1SSL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1SSL OCA]. 

==Reference==
Insights into function of PSI domains from structure of the Met receptor PSI domain., Kozlov G, Perreault A, Schrag JD, Park M, Cygler M, Gehring K, Ekiel I, Biochem Biophys Res Commun. 2004 Aug 13;321(1):234-40. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15358240 15358240]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Cygler, M.]]
[[Category: Ekiel, I.]]
[[Category: Gehring, K.]]
[[Category: Kozlov, G.]]
[[Category: Perreault, A.]]
[[Category: Schrag, J.D.]]
[[Category: cysteine knot]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:17:21 2007''