View source for 3oxt


==Human cAMP-dependent protein kinase in complex with an inhibitor==
<StructureSection load='3oxt' size='340' side='right'caption='[[3oxt]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3oxt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OXT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3SB:(2S)-2-AMINO-N-[(1E)-(2,4-DIHYDROXY-6-METHYLPHENYL)METHYLIDENE]-2-PHENYLETHANEHYDRAZIDE'>3SB</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oxt OCA], [https://pdbe.org/3oxt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oxt RCSB], [https://www.ebi.ac.uk/pdbsum/3oxt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oxt ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IPKA_HUMAN IPKA_HUMAN] Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

==See Also==
*[[CAMP-dependent protein kinase 3D structures|CAMP-dependent protein kinase 3D structures]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Heine A]]
[[Category: Klebe G]]
[[Category: Koester H]]