View source for 1qhv

[[Image:1qhv.jpg|left|200px]]

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{{STRUCTURE_1qhv|  PDB=1qhv  |  SCENE=  }} 

'''HUMAN ADENOVIRUS SEROTYPE 2 FIBRE HEAD'''


==Overview==
Adenovirus binds to its receptor via the head domain of its fiber protein. We have crystallized the adenovirus serotype 2 (subgroup C) receptor binding domain and solved the structure at 1.5 A resolution by the molecular replacement technique using the known adenovirus type 5 head structure. Included in the high-resolution model are 306 water molecules, five alternative side chain conformations, and individual anisotropic temperature factors for each atom. The overall structure of the serotype 2 head is very similar to its serotype 5 homologue, apart from differences in some of the flexible loops. All but subgroup B adenoviruses are believed to use the recently identified protein CAR (Coxsackievirus and adenovirus receptor) as receptor. By comparison of the two structures and sequence alignment of CAR binding and non-CAR binding serotype fiber heads, we discuss possible receptor binding sites and propose a receptor binding site in a crevice between two monomers on the side of the trimer. The structural basis of the extraordinary stability of the fiber head trimer is also discussed.

==About this Structure==
1QHV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_adenovirus_2 Human adenovirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QHV OCA]. 

==Reference==
Structure of the human adenovirus serotype 2 fiber head domain at 1.5 A resolution., van Raaij MJ, Louis N, Chroboczek J, Cusack S, Virology. 1999 Sep 30;262(2):333-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10502512 10502512]
[[Category: Human adenovirus 2]]
[[Category: Single protein]]
[[Category: Chroboczek, J.]]
[[Category: Cusack, S.]]
[[Category: Louis, N.]]
[[Category: Raaij, M J.Van.]]
[[Category: Extra-ordinary stability]]
[[Category: Receptor binding]]
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