View source for 7zxa


==Crystal structure of human cathepsin L with covalently bound aloxistatin (E-64D)==
<StructureSection load='7zxa' size='340' side='right'caption='[[7zxa]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7zxa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZXA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=E6D:ETHYL+(3S)-3-HYDROXY-4-({(2S)-4-METHYL-1-[(3-METHYLBUTYL)AMINO]-1-OXOPENTAN-2-YL}AMINO)-4-OXOBUTANOATE'>E6D</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zxa OCA], [https://pdbe.org/7zxa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zxa RCSB], [https://www.ebi.ac.uk/pdbsum/7zxa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zxa ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CATL1_HUMAN CATL1_HUMAN] Important for the overall degradation of proteins in lysosomes.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chapman HN]]
[[Category: Ewert W]]
[[Category: Falke S]]
[[Category: Guenther S]]
[[Category: Hinrichs W]]
[[Category: Karnicar K]]
[[Category: Lieske J]]
[[Category: Lindic N]]
[[Category: Loboda J]]
[[Category: Meents A]]
[[Category: Reinke PYA]]
[[Category: Sekirnik A]]
[[Category: Turk D]]
[[Category: Usenik A]]