View source for 1rzk

[[Image:1rzk.gif|left|200px]]<br />
<applet load="1rzk" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1rzk, resolution 2.90&Aring;" />
'''HIV-1 YU2 GP120 ENVELOPE GLYCOPROTEIN COMPLEXED WITH CD4 AND INDUCED NEUTRALIZING ANTIBODY 17B'''<br />

==Overview==
The conserved surface of the HIV-1 gp120 envelope glycoprotein that binds, to the HIV-1 coreceptor is protected from humoral recognition by multiple, layers of camouflage. Here we present sequence and genomic analyses for 12, antibodies that pierce these defenses and determine the crystal structures, of 5. The data reveal mechanisms and atomic-level details for three, unusual immune features: posttranslational mimicry of coreceptor by, tyrosine sulfation of antibody, an alternative molecular mechanism, controlling such sulfation, and highly selective V(H)-gene usage. When, confronted by extraordinary viral defenses, the immune system unveils, novel adaptive capabilities, with tyrosine sulfation enhancing the, vocabulary of antigen recognition.

==About this Structure==
1RZK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with NDG and NAG as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1RZK OCA]. 

==Reference==
Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120., Huang CC, Venturi M, Majeed S, Moore MJ, Phogat S, Zhang MY, Dimitrov DS, Hendrickson WA, Robinson J, Sodroski J, Wyatt R, Choe H, Farzan M, Kwong PD, Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2706-11. Epub 2004 Feb 23. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14981267 14981267]
[[Category: Homo sapiens]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Single protein]]
[[Category: Choe, H.]]
[[Category: Dimitrov, D.S.]]
[[Category: Farzan, M.]]
[[Category: Hendrickson, W.A.]]
[[Category: Huang, C.C.]]
[[Category: Kwong, P.D.]]
[[Category: Majeed, S.]]
[[Category: Moore, M.J.]]
[[Category: Phogat, S.]]
[[Category: Robinson, J.]]
[[Category: Sodroski, J.]]
[[Category: Venturi, M.]]
[[Category: Wyatt, R.]]
[[Category: Zhang, M.Y.]]
[[Category: NAG]]
[[Category: NDG]]
[[Category: complex (hiv envelope protein/cd4/fab); hiv-1 exterior envelope gp120 from laboratory-adapted isolate; hxbc2; surface t-cell glycoprotein cd4; antigen-binding fragment of human immunoglobulin 17b]]

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