View source for 8hry


==Cryo-EM structure of human NTCP-myr-preS1-YN9016Fab complex==
<StructureSection load='8hry' size='340' side='right'caption='[[8hry]], [[Resolution|resolution]] 3.11&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8hry]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_B_virus Hepatitis B virus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Ondatra_zibethicus Ondatra zibethicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HRY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.11&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hry OCA], [https://pdbe.org/8hry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hry RCSB], [https://www.ebi.ac.uk/pdbsum/8hry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hry ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/NTCP_HUMAN NTCP_HUMAN] The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/NTCP_HUMAN NTCP_HUMAN] As a major transporter of conjugated bile salts from plasma into the hepatocyte, it has a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins. It exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. Able to transport taurocholate, cholate, and the non-bile acid estron sulfate (PubMed:14660639, PubMed:24867799).<ref>PMID:14660639</ref> <ref>PMID:24867799</ref>   (Microbial infection) Acts as a receptor for hepatitis B virus.<ref>PMID:23150796</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Hepatitis B virus]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Ondatra zibethicus]]
[[Category: Asami J]]
[[Category: Ohto U]]
[[Category: Shimizu T]]