View source for 1ocr

[[Image:1ocr.gif|left|200px]]

<!--
The line below this paragraph, containing "STRUCTURE_1ocr", creates the "Structure Box" on the page.
You may change the PDB parameter (which sets the PDB file loaded into the applet) 
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
or leave the SCENE parameter empty for the default display.
-->
{{STRUCTURE_1ocr|  PDB=1ocr  |  SCENE=  }} 

'''BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE'''


==Overview==
Crystal structures of bovine heart cytochrome c oxidase in the fully oxidized, fully reduced, azide-bound, and carbon monoxide-bound states were determined at 2.30, 2.35, 2.9, and 2.8 angstrom resolution, respectively. An aspartate residue apart from the O2 reduction site exchanges its effective accessibility to the matrix aqueous phase for one to the cytosolic phase concomitantly with a significant decrease in the pK of its carboxyl group, on reduction of the metal sites. The movement indicates the aspartate as the proton pumping site. A tyrosine acidified by a covalently linked imidazole nitrogen is a possible proton donor for the O2 reduction by the enzyme.

==About this Structure==
1OCR is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OCR OCA]. 

==Reference==
Redox-coupled crystal structural changes in bovine heart cytochrome c oxidase., Yoshikawa S, Shinzawa-Itoh K, Nakashima R, Yaono R, Yamashita E, Inoue N, Yao M, Fei MJ, Libeu CP, Mizushima T, Yamaguchi H, Tomizaki T, Tsukihara T, Science. 1998 Jun 12;280(5370):1723-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9624044 9624044]
[[Category: Bos taurus]]
[[Category: Cytochrome-c oxidase]]
[[Category: Protein complex]]
[[Category: Tsukihara, T.]]
[[Category: Yao, M.]]
[[Category: Cytochrome c oxidase]]
[[Category: Reduced]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:40:25 2008''