View source for 8cyh


==Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics==
<StructureSection load='8cyh' size='340' side='right'caption='[[8cyh]], [[Resolution|resolution]] 3.38&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8cyh]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CYH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CYH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cyh OCA], [https://pdbe.org/8cyh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cyh RCSB], [https://www.ebi.ac.uk/pdbsum/8cyh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cyh ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/MSLN_HUMAN MSLN_HUMAN] Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer.
== Function ==
[https://www.uniprot.org/uniprot/MSLN_HUMAN MSLN_HUMAN] Membrane-anchored forms may play a role in cellular adhesion.<ref>PMID:8288629</ref> <ref>PMID:14676194</ref>   Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.<ref>PMID:8288629</ref> <ref>PMID:14676194</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bandaranayake AD]]
[[Category: Carter J]]
[[Category: Chan MK]]
[[Category: Clarke M]]
[[Category: Correnti CE]]
[[Category: Friend DJ]]
[[Category: Lin I]]
[[Category: Mehlin C]]
[[Category: Meshinchi S]]
[[Category: Olson JM]]
[[Category: Pilat K]]
[[Category: Ruff RO]]
[[Category: Rupert PB]]
[[Category: Strong RK]]