View source for 4z2d


==Quinolone(Levofloxacin)-DNA cleavage complex of gyrase from S. pneumoniae==
<StructureSection load='4z2d' size='340' side='right'caption='[[4z2d]], [[Resolution|resolution]] 3.38&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4z2d]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z2D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z2D FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LFX:(3S)-9-FLUORO-3-METHYL-10-(4-METHYLPIPERAZIN-1-YL)-7-OXO-2,3-DIHYDRO-7H-[1,4]OXAZINO[2,3,4-IJ]QUINOLINE-6-CARBOXYLIC+ACID'>LFX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z2d OCA], [https://pdbe.org/4z2d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z2d RCSB], [https://www.ebi.ac.uk/pdbsum/4z2d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z2d ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GYRA_STRR6 GYRA_STRR6] A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01897]

==See Also==
*[[Gyrase 3D Structures|Gyrase 3D Structures]]
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Streptococcus pneumoniae]]
[[Category: Crevel IM-T]]
[[Category: Fisher LM]]
[[Category: Laponogov I]]
[[Category: Pan X-S]]
[[Category: Sanderson MR]]
[[Category: Selvarajah J]]
[[Category: Veselkov DA]]