View source for 4xcx


==METHYLTRANSFERASE DOMAIN OF SMALL RNA 2'-O-METHYLTRANSFERASE==
<StructureSection load='4xcx' size='340' side='right'caption='[[4xcx]], [[Resolution|resolution]] 2.84&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4xcx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XCX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XCX FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xcx OCA], [https://pdbe.org/4xcx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xcx RCSB], [https://www.ebi.ac.uk/pdbsum/4xcx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xcx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HENMT_HUMAN HENMT_HUMAN] Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis (By similarity).
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Brown PJ]]
[[Category: Dong A]]
[[Category: Edwards AM]]
[[Category: Li Y]]
[[Category: Walker JR]]
[[Category: Wernimont A]]
[[Category: Wu H]]
[[Category: Zeng H]]