View source for 1kcu

[[Image:1kcu.jpg|left|200px]]

<!--
The line below this paragraph, containing "STRUCTURE_1kcu", creates the "Structure Box" on the page.
You may change the PDB parameter (which sets the PDB file loaded into the applet) 
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
or leave the SCENE parameter empty for the default display.
-->
{{STRUCTURE_1kcu|  PDB=1kcu  |  SCENE=  }} 

'''CRYSTAL STRUCTURE OF ANTIBODY PC287'''


==Overview==
Crystal structures of distinct mAbs that recognize a common epitope of a peptide Ag have been determined and analyzed in the unbound and bound forms. These Abs display dissimilar binding site structures in the absence of the Ag. The dissimilarity is primarily expressed in the conformations of complementarity-determining region H3, which is responsible for defining the epitope specificity. Interestingly, however, the three Abs exhibit similar complementarity-determining region conformations in the Ag binding site while recognizing the common epitope, indicating that different pathways of binding are used for Ag recognition. The epitope also exhibits conformational similarity when bound to each of these Abs, although the peptide Ag was otherwise flexible. The observed conformational convergence in the epitope and the Ag binding site was facilitated by the plasticity in the nature of interactions.

==About this Structure==
1KCU is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KCU OCA]. 

==Reference==
Epitope recognition by diverse antibodies suggests conformational convergence in an antibody response., Nair DT, Singh K, Siddiqui Z, Nayak BP, Rao KV, Salunke DM, J Immunol. 2002 Mar 1;168(5):2371-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11859128 11859128]
[[Category: Mus musculus]]
[[Category: Protein complex]]
[[Category: Nair, D T.]]
[[Category: Nayak, B P.]]
[[Category: Rao, K V.S.]]
[[Category: Salunke, D M.]]
[[Category: Siddiqui, Z.]]
[[Category: Singh, K.]]
[[Category: Anti-peptide antibody]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 22:35:10 2008''