View source for 4uvj


==Cohesin subunit Scc3 from yeast, 674-1072==
<StructureSection load='4uvj' size='340' side='right'caption='[[4uvj]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4uvj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UVJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UVJ FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uvj OCA], [https://pdbe.org/4uvj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uvj RCSB], [https://www.ebi.ac.uk/pdbsum/4uvj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uvj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SCC3_YEAST SCC3_YEAST] Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the MCD1/SCC1 subunit of the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
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== Publication Abstract from PubMed ==
Sister chromatid cohesion involves entrapment of sister DNAs by a cohesin ring created through association of a kleisin subunit (Scc1) with ATPase heads of Smc1/Smc3 heterodimers. Cohesin's association with chromatin involves subunits recruited by Scc1: Wapl, Pds5, and Scc3/SA, in addition to Scc2/4 loading complex. Unlike Pds5, Wapl, and Scc2/4, Scc3s are encoded by all eukaryotic genomes. Here, a crystal structure of Scc3 reveals a hook-shaped protein composed of tandem alpha helices. Its N-terminal domain contains a conserved and essential surface (CES) present even in organisms lacking Pds5, Wapl, and Scc2/4, while its C-terminal domain binds a section of the kleisin Scc1. Scc3 turns over in G2/M while maintaining cohesin's association with chromosomes and it promotes de-acetylation of Smc3 upon Scc1 cleavage.

Structure and function of cohesin's Scc3/SA regulatory subunit.,Roig MB, Lowe J, Chan KL, Beckouet F, Metson J, Nasmyth K FEBS Lett. 2014 Aug 27. pii: S0014-5793(14)00617-6. doi:, 10.1016/j.febslet.2014.08.015. PMID:25171859<ref>PMID:25171859</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Lowe J]]
[[Category: Nasmyth K]]
[[Category: Roig MB]]