View source for 4txk


==Construct of MICAL-1 containing the monooxygenase and calponin homology domains==
<StructureSection load='4txk' size='340' side='right'caption='[[4txk]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4txk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TXK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TXK FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4txk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4txk OCA], [https://pdbe.org/4txk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4txk RCSB], [https://www.ebi.ac.uk/pdbsum/4txk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4txk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MICA1_MOUSE MICA1_MOUSE] Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments (By similarity). Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4.
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</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Alqassim SS]]
[[Category: Amzel LM]]
[[Category: Bianchet MA]]