View source for 7z5b


==Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH013546==
<StructureSection load='7z5b' size='340' side='right'caption='[[7z5b]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7z5b]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Z5B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Z5B FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IFT:2-[4-(2,4-dimethyl-1~{H}-imidazol-5-yl)phenyl]-~{N}-(4,5,6,7-tetrahydro-1,2-benzoxazol-3-yl)ethanamide'>IFT</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z5b OCA], [https://pdbe.org/7z5b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z5b RCSB], [https://www.ebi.ac.uk/pdbsum/7z5b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z5b ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/OGG1_MOUSE OGG1_MOUSE] DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
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</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Scaletti E]]
[[Category: Stenmark P]]