View source for 8dth


==Cryo-EM structure of Arabidopsis SPY alternative conformation 2==
<StructureSection load='8dth' size='340' side='right'caption='[[8dth]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8dth]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DTH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DTH FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dth OCA], [https://pdbe.org/8dth PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dth RCSB], [https://www.ebi.ac.uk/pdbsum/8dth PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dth ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SPY_ARATH SPY_ARATH] Probable O-linked N-acetylglucosamine transferase (OGT) involved in various processes such as gibberellin (GA) signaling pathway and circadian clock. OGTs catalyze the addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine. Probably acts by adding O-linked sugars to yet unknown proteins. Acts as a repressor of GA signaling pathway to inhibit hypocotyl elongation. Functions with GIGANTEA (GI) in pathways controlling flowering, circadian cotyledon movements and hypocotyl elongation. Acts as a light-regulated promoter of elongation via its interaction with GI. Acts as an activator of cytokinin signaling. Required with SEC for gamete and seed development (PubMed:12136030). Its OGT activity has been proved in vitro but not in vivo (Ref.5, PubMed:11457967, PubMed:12136030, PubMed:15155885, PubMed:15608330, PubMed:8799194). Possesses O-fucosyltransferase activity on specific serine and threonine residues (PubMed:28244988). Mediates O-fucosylation of the DELLA protein RGA, a repressor of the GA signaling pathway (PubMed:28244988). O-fucosylation enhances RGA activity by promoting RGA binding to key transcription factors in brassinosteroid and light-signaling pathways (PubMed:28244988). Regulates root hair patterning upstream of the transcription factor WER, independently of DELLA proteins and GA signaling (PubMed:32928908). Involved in abscisic acid (ABA) signaling partly through functional ABAR (PubMed:34712252). Mediates O-fucosylation of CPN20 that may depress ABA responses during seed germination and seedling development (PubMed:34712252). Involved in the modulation of the pace of the circadian clock by mediating O-fucosylation of APRR5, one of the core circadian clock components (PubMed:31899321). O-fucosylation promotes APRR5 proteolysis (PubMed:31899321).<ref>PMID:11457967</ref> <ref>PMID:12136030</ref> <ref>PMID:15155885</ref> <ref>PMID:15608330</ref> <ref>PMID:28244988</ref> <ref>PMID:31899321</ref> <ref>PMID:32928908</ref> <ref>PMID:34712252</ref> <ref>PMID:8799194</ref> <ref>PMID:12136030</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Bartesaghi A]]
[[Category: Borgnia MJ]]
[[Category: Dillard L]]
[[Category: Kumar S]]
[[Category: Zhou P]]
[[Category: Zhou Y]]