View source for 1jzd

[[Image:1jzd.gif|left|200px]]

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{{STRUCTURE_1jzd|  PDB=1jzd  |  SCENE=  }} 

'''DsbC-DsbDalpha complex'''


==Overview==
The Escherichia coli disulfide bond isomerase DsbC rearranges incorrect disulfide bonds during oxidative protein folding. It is specifically activated by the periplasmic N-terminal domain (DsbDalpha) of the transmembrane electron transporter DsbD. An intermediate of the electron transport reaction was trapped, yielding a covalent DsbC-DsbDalpha complex. The 2.3 A crystal structure of the complex shows for the first time the specific interactions between two thiol oxidoreductases. DsbDalpha is a novel thiol oxidoreductase with the active site cysteines embedded in an immunoglobulin fold. It binds into the central cleft of the V-shaped DsbC dimer, which assumes a closed conformation on complex formation. Comparison of the complex with oxidized DsbDalpha reveals major conformational changes in a cap structure that regulates the accessibility of the DsbDalpha active site. Our results explain how DsbC is selectively activated by DsbD using electrons derived from the cytoplasm.

==About this Structure==
1JZD is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZD OCA]. 

==Reference==
The disulfide bond isomerase DsbC is activated by an immunoglobulin-fold thiol oxidoreductase: crystal structure of the DsbC-DsbDalpha complex., Haebel PW, Goldstone D, Katzen F, Beckwith J, Metcalf P, EMBO J. 2002 Sep 16;21(18):4774-84. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12234918 12234918]
[[Category: Escherichia coli]]
[[Category: Protein complex]]
[[Category: Beckwith, J.]]
[[Category: Goldstone, D.]]
[[Category: Haebel, P W.]]
[[Category: Katzen, F.]]
[[Category: Metcalf, P.]]
[[Category: Protein-protein complex]]
[[Category: Reaction intermediate]]
[[Category: Thiol disulfide oxidoreductase]]
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