View source for 2lb5


==Refined Structural Basis for the Photoconversion of A Phytochrome to the Activated FAR-RED LIGHT-ABSORBING Form==
<StructureSection load='2lb5' size='340' side='right'caption='[[2lb5]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2lb5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synechococcus_sp._JA-2-3B'a(2-13) Synechococcus sp. JA-2-3B'a(2-13)]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LB5 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYC:PHYCOCYANOBILIN'>CYC</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lb5 OCA], [https://pdbe.org/2lb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lb5 RCSB], [https://www.ebi.ac.uk/pdbsum/2lb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lb5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q2JIZ5_SYNJB Q2JIZ5_SYNJB] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Phytochromes are a collection of bilin-containing photoreceptors that regulate numerous photoresponses in plants and microorganisms through their ability to photointerconvert between a red-light-absorbing, ground state (Pr) and a far-red-light-absorbing, photoactivated state (Pfr). Although the structures of several phytochromes as Pr have been determined, little is known about the structure of Pfr and how it initiates signalling. Here we describe the three-dimensional solution structure of the bilin-binding domain as Pfr, using the cyanobacterial phytochrome from Synechococcus OSB'. Contrary to predictions, light-induced rotation of the A pyrrole ring but not the D ring is the primary motion of the chromophore during photoconversion. Subsequent rearrangements within the protein then affect intradomain and interdomain contact sites within the phytochrome dimer. On the basis of our models, we propose that phytochromes act by propagating reversible light-driven conformational changes in the bilin to altered contacts between the adjacent output domains, which in most phytochromes direct differential phosphotransfer.

Structural basis for the photoconversion of a phytochrome to the activated Pfr form.,Ulijasz AT, Cornilescu G, Cornilescu CC, Zhang J, Rivera M, Markley JL, Vierstra RD Nature. 2010 Jan 14;463(7278):250-4. PMID:20075921<ref>PMID:20075921</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2lb5" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Cornilescu CC]]
[[Category: Cornilescu G]]
[[Category: Markley JL]]
[[Category: Ulijasz AT]]
[[Category: Vierstra RD]]