View source for 1jg5

[[Image:1jg5.jpg|left|200px]]

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{{STRUCTURE_1jg5|  PDB=1jg5  |  SCENE=  }} 

'''CRYSTAL STRUCTURE OF RAT GTP CYCLOHYDROLASE I FEEDBACK REGULATORY PROTEIN, GFRP'''


==Overview==
Tetrahydrobiopterin, the cofactor required for hydroxylation of aromatic amino acids regulates its own synthesis in mammals through feedback inhibition of GTP cyclohydrolase I. This mechanism is mediated by a regulatory subunit called GTP cyclohydrolase I feedback regulatory protein (GFRP). The 2.6 A resolution crystal structure of rat GFRP shows that the protein forms a pentamer. This indicates a model for the interaction of mammalian GTP cyclohydrolase I with its regulator, GFRP. Kinetic investigations of human GTP cyclohydrolase I in complex with rat and human GFRP showed similar regulatory effects of both GFRP proteins.

==About this Structure==
1JG5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JG5 OCA]. 

==Reference==
Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, GFRP., Bader G, Schiffmann S, Herrmann A, Fischer M, Gutlich M, Auerbach G, Ploom T, Bacher A, Huber R, Lemm T, J Mol Biol. 2001 Oct 5;312(5):1051-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11580249 11580249]
[[Category: Rattus norvegicus]]
[[Category: Single protein]]
[[Category: Auerbach, G.]]
[[Category: Bacher, A.]]
[[Category: Bader, G.]]
[[Category: Fischer, M.]]
[[Category: Gutlich, M.]]
[[Category: Herrmann, A.]]
[[Category: Huber, R.]]
[[Category: Lemm, T.]]
[[Category: Ploom, T.]]
[[Category: Schiffmann, S.]]
[[Category: Alpha/beta structure]]
[[Category: Beta sheet]]
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