View source for 4m4c


==Crystal structure of Rhodostomin ARGDP mutant==
<StructureSection load='4m4c' size='340' side='right'caption='[[4m4c]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4m4c]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M4C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M4C FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m4c OCA], [https://pdbe.org/4m4c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m4c RCSB], [https://www.ebi.ac.uk/pdbsum/4m4c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m4c ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VM2RH_CALRH VM2RH_CALRH] Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity).  Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3).
__TOC__
</StructureSection>
[[Category: Calloselasma rhodostoma]]
[[Category: Large Structures]]
[[Category: Chang YT]]
[[Category: Chen CY]]
[[Category: Chuang WJ]]
[[Category: Jeng WY]]
[[Category: Shiu JH]]