View source for 4l7g


==Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of 2-hydroxy-benzylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against Beta-Secretase-1 (BACE1)==
<StructureSection load='4l7g' size='340' side='right'caption='[[4l7g]], [[Resolution|resolution]] 1.38&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4l7g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L7G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L7G FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1W0:(3AS,7AR)-7A-[3-(PYRIMIDIN-5-YL)PHENYL]-3A,6,7,7A-TETRAHYDRO-4H-PYRANO[4,3-D][1,3]OXAZOL-2-AMINE'>1W0</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l7g OCA], [https://pdbe.org/4l7g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l7g RCSB], [https://www.ebi.ac.uk/pdbsum/4l7g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l7g ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> 

==See Also==
*[[Beta secretase 3D structures|Beta secretase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Dutcher D]]
[[Category: Geck Do MK]]
[[Category: Huestis MP]]
[[Category: Hunt KW]]
[[Category: Liu W]]
[[Category: Purkey H]]
[[Category: Siu M]]
[[Category: Smith D]]
[[Category: Vigers G]]
[[Category: Volgraf M]]
[[Category: Wang W]]
[[Category: Wu P]]
[[Category: Yu C]]