View source for 1hre

[[Image:1hre.gif|left|200px]]<br />
<applet load="1hre" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1hre" />
'''SOLUTION STRUCTURE OF THE EPIDERMAL GROWTH FACTOR-LIKE DOMAIN OF HEREGULIN-ALPHA, A LIGAND FOR P180ERB4'''<br />

==Overview==
p185erbB-2 and p180erbB-4 are epidermal growth factor (EGF) receptor-like, tyrosine kinases, whose co-expression is observed in many breast, carcinomas. Heregulins (HRGs), which contain an immunoglobulin unit and an, EGF-like domain, bind to p180erbB-4 and activate p180erbB-4 and p185erbB-2, through transphosphorylation or receptor heterodimerization. The EGF-like, domain is sufficient for the activation. Despite the sequence similarity, no cross activity is seen between the p180erbB-4 ligands (HRGs) and the, p170erbB-1 ligands [EGF and transforming growth factor (TGF)-alpha]. To, investigate the structural basis of receptor specificity, we have, determined the solution structure of the EGF-like domain of HRG-alpha by, two-dimensional 1H nuclear magnetic resonance spectroscopy and simulated, annealing calculations. Though its main-chain fold is similar to those of, EGF and TGF-alpha, distinctive structural features are observed on the, molecular surface including an ionic cluster and hydrophobic patches, which afford HRG-alpha the specific affinity for p180erbB-4. The structure, should provide a basis for the structure-activity relationship of HRGs and, for the design of drugs which prevent progression of breast cancer.

==Disease==
Known diseases associated with this structure: Fibromatosis, gingival, 2 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=605544 605544]], Schizophrenia, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=142445 142445]]

==About this Structure==
1HRE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HRE OCA]. 

==Reference==
Solution structure of the epidermal growth factor-like domain of heregulin-alpha, a ligand for p180erbB-4., Nagata K, Kohda D, Hatanaka H, Ichikawa S, Matsuda S, Yamamoto T, Suzuki A, Inagaki F, EMBO J. 1994 Aug 1;13(15):3517-23. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8062828 8062828]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Hatanaka, H.]]
[[Category: Ichikawa, S.]]
[[Category: Inagaki, F.]]
[[Category: Kohda, D.]]
[[Category: Nagata, K.]]
[[Category: growth factor]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:21:23 2007''