View source for 1j5j

[[Image:1j5j.jpg|left|200px]]

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{{STRUCTURE_1j5j|  PDB=1j5j  |  SCENE=  }} 

'''Solution structure of HERG-specific scorpion toxin BeKm-1'''


==Overview==
The scorpion toxin BeKm-1 is unique among a variety of known short scorpion toxins affecting potassium channels in its selective action on ether-a-go-go-related gene (ERG)-type channels. BeKm-1 shares the common molecular scaffold with other short scorpion toxins. The toxin spatial structure resolved by NMR consists of a short alpha-helix and a triple-stranded antiparallel beta-sheet. By toxin mutagenesis study we identified the residues that are important for the binding of BeKm-1 to the human ERG K+ (HERG) channel. The most critical residues (Tyr-11, Lys-18, Arg-20, Lys-23) are located in the alpha-helix and following loop whereas the "traditional" functional site of other short scorpion toxins is formed by residues from the beta-sheet. Thus the unique location of the binding site of BeKm-1 provides its specificity toward the HERG channel.

==About this Structure==
1J5J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mesobuthus_eupeus Mesobuthus eupeus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J5J OCA]. 

==Reference==
New binding site on common molecular scaffold provides HERG channel specificity of scorpion toxin BeKm-1., Korolkova YV, Bocharov EV, Angelo K, Maslennikov IV, Grinenko OV, Lipkin AV, Nosyreva ED, Pluzhnikov KA, Olesen SP, Arseniev AS, Grishin EV, J Biol Chem. 2002 Nov 8;277(45):43104-9. Epub 2002 Jul 31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12151390 12151390]
[[Category: Mesobuthus eupeus]]
[[Category: Single protein]]
[[Category: Angelo, K.]]
[[Category: Arseniev, A S.]]
[[Category: Bocharov, E V.]]
[[Category: Grinenko, O V.]]
[[Category: Grishin, E V.]]
[[Category: Korolokova, Y V.]]
[[Category: Lipkin, A V.]]
[[Category: Maslennikov, I V.]]
[[Category: Nosireva, E D.]]
[[Category: Olesen, S P.]]
[[Category: Pluzhnikov, K A.]]
[[Category: Alpha-beta motif]]
[[Category: Cysteine-knot motif]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 20:49:54 2008''