View source for 1ihk

[[Image:1ihk.jpg|left|200px]]

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{{STRUCTURE_1ihk|  PDB=1ihk  |  SCENE=  }} 

'''CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR 9 (FGF9)'''


==Overview==
Fibroblast growth factors (FGFs) constitute a large family of heparin-binding growth factors with diverse biological activities. FGF9 was originally described as glia-activating factor and is expressed in the nervous system as a potent mitogen for glia cells. Unlike most FGFs, FGF9 forms dimers in solution with a K(d) of 680 nm. To elucidate the molecular mechanism of FGF9 dimerization, the crystal structure of FGF9 was determined at 2.2 A resolution. FGF9 adopts a beta-trefoil fold similar to other FGFs. However, unlike other FGFs, the N- and C-terminal regions outside the beta-trefoil core in FGF9 are ordered and involved in the formation of a 2-fold crystallographic dimer. A significant surface area (&gt;2000 A(2)) is buried in the dimer interface that occludes a major receptor binding site of FGF9. Thus, we propose an autoinhibitory mechanism for FGF9 that is dependent on sequences outside of the beta-trefoil core. Moreover, a model is presented providing a molecular basis for the preferential affinity of FGF9 toward FGFR3.

==About this Structure==
1IHK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IHK OCA]. 

==Reference==
Crystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibition., Plotnikov AN, Eliseenkova AV, Ibrahimi OA, Shriver Z, Sasisekharan R, Lemmon MA, Mohammadi M, J Biol Chem. 2001 Feb 9;276(6):4322-9. Epub 2000 Nov 1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11060292 11060292]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Eliseenkova, A V.]]
[[Category: Ibrahimi, O A.]]
[[Category: Lemmon, M A.]]
[[Category: Mohammadi, M.]]
[[Category: Plotnikov, A N.]]
[[Category: B-trefoil fold]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 20:00:28 2008''