View source for 1ih4

[[Image:1ih4.gif|left|200px]]

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{{STRUCTURE_1ih4|  PDB=1ih4  |  SCENE=  }} 

'''Multi-Conformation Crystal Structure of GGm5CGCC'''


==Overview==
The transition between B- and A-DNA was first observed nearly 50 years ago. We have now mapped this transformation through a set of single-crystal structures of the sequence d(GGCGCC)2, with various intermediates being trapped by methylating or brominating the cytosine bases. The resulting pathway progresses through 13 conformational steps, with a composite structure that pairs A-nucleotides with complementary B-nucleotides serving as a distinct transition intermediate. The details of each step in the conversion of B- to A-DNA are thus revealed at the atomic level, placing intermediates for this and other sequences in the context of a common pathway.

==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IH4 OCA]. 

==Reference==
A crystallographic map of the transition from B-DNA to A-DNA., Vargason JM, Henderson K, Ho PS, Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7265-70. Epub 2001 Jun 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11390969 11390969]
[[Category: Henderson, K.]]
[[Category: Ho, P S.]]
[[Category: Vargason, J M.]]
[[Category: B to a dna transition]]
[[Category: Dna transition]]
[[Category: Structural transition]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 19:59:37 2008''