View source for 4dcl


==Computationally Designed Self-assembling tetrahedron protein, T308, Crystallized in space group F23==
<StructureSection load='4dcl' size='340' side='right'caption='[[4dcl]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4dcl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DCL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DCL FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dcl OCA], [https://pdbe.org/4dcl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dcl RCSB], [https://www.ebi.ac.uk/pdbsum/4dcl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dcl ProSAT]</span></td></tr>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/ATRF2_STAAC ATRF2_STAAC]] 
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== Publication Abstract from PubMed ==
We describe a general computational method for designing proteins that self-assemble to a desired symmetric architecture. Protein building blocks are docked together symmetrically to identify complementary packing arrangements, and low-energy protein-protein interfaces are then designed between the building blocks in order to drive self-assembly. We used trimeric protein building blocks to design a 24-subunit, 13-nm diameter complex with octahedral symmetry and a 12-subunit, 11-nm diameter complex with tetrahedral symmetry. The designed proteins assembled to the desired oligomeric states in solution, and the crystal structures of the complexes revealed that the resulting materials closely match the design models. The method can be used to design a wide variety of self-assembling protein nanomaterials.

Computational design of self-assembling protein nanomaterials with atomic level accuracy.,King NP, Sheffler W, Sawaya MR, Vollmar BS, Sumida JP, Andre I, Gonen T, Yeates TO, Baker D Science. 2012 Jun 1;336(6085):1171-4. PMID:22654060<ref>PMID:22654060</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Baker D]]
[[Category: King NP]]
[[Category: Sawaya MR]]
[[Category: Sheffler W]]
[[Category: Yeates TO]]