View source for 7vdh


==Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state2==
<StructureSection load='7vdh' size='340' side='right'caption='[[7vdh]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7vdh]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VDH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VDH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6IB:2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-~{N}-methyl-ethanamine'>6IB</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vdh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vdh OCA], [https://pdbe.org/7vdh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vdh RCSB], [https://www.ebi.ac.uk/pdbsum/7vdh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vdh ProSAT]</span></td></tr>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/MRGX2_HUMAN MRGX2_HUMAN]] Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core (PubMed:25517090). Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction (By similarity). Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A.[UniProtKB:Q3KNA1]<ref>PMID:15823563</ref> <ref>PMID:21441599</ref> <ref>PMID:22069323</ref> <ref>PMID:23698749</ref> <ref>PMID:24930830</ref> <ref>PMID:25517090</ref> <ref>PMID:12915402</ref> 

==See Also==
*[[Transducin 3D structures|Transducin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Li Y]]
[[Category: Yang F]]