View source for 1ial

[[Image:1ial.gif|left|200px]]

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{{STRUCTURE_1ial|  PDB=1ial  |  SCENE=  }} 

'''IMPORTIN ALPHA, MOUSE'''


==Overview==
Importin alpha is the nuclear import receptor that recognizes classical monopartite and bipartite nuclear localization signals (NLSs). The structure of mouse importin alpha has been determined at 2.5 A resolution. The structure shows a large C-terminal domain containing armadillo repeats, and a less structured N-terminal importin beta-binding domain containing an internal NLS bound to the NLS-binding site. The structure explains the regulatory switch between the cytoplasmic, high-affinity form, and the nuclear, low-affinity form for NLS binding of the nuclear import receptor predicted by the current models of nuclear import. Importin beta conceivably converts the low- to high-affinity form by binding to a site overlapping the autoinhibitory sequence. The structure also has implications for understanding NLS recognition, and the structures of armadillo and HEAT repeats.

==About this Structure==
1IAL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IAL OCA]. 

==Reference==
Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alpha., Kobe B, Nat Struct Biol. 1999 Apr;6(4):388-97. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10201409 10201409]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Kobe, B.]]
[[Category: Armadillo repeat]]
[[Category: Autoinhibition]]
[[Category: Intrasteric regulation]]
[[Category: Nuclear import receptor]]
[[Category: Nuclear localization signal]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 19:46:31 2008''