View source for 4btx


==Crystal structure of human vascular adhesion protein-1 in complex with pyridazinone inhibitors==
<StructureSection load='4btx' size='340' side='right'caption='[[4btx]], [[Resolution|resolution]] 2.78&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4btx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BTX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BTX FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TPQ:5-(2-CARBOXY-2-AMINOETHYL)-2-HYDROXY-1,4-BENZOQUINONE'>TPQ</scene>, <scene name='pdbligand=WF8:5-ISOPROPYLAMINO-2-PHENYL-6-(1H-1,2,4-TRIAZOL-5-YL)-3(2H)-PYRIDAZINONE'>WF8</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4btx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4btx OCA], [https://pdbe.org/4btx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4btx RCSB], [https://www.ebi.ac.uk/pdbsum/4btx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4btx ProSAT]</span></td></tr>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/AOC3_HUMAN AOC3_HUMAN]] Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has a monoamine oxidase activity. May play a role in adipogenesis.<ref>PMID:9653080</ref> <ref>PMID:17400359</ref> <ref>PMID:19588076</ref> 

==See Also==
*[[Copper amine oxidase 3D structures|Copper amine oxidase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bligt-Linden E]]
[[Category: Fulop F]]
[[Category: Lazar L]]
[[Category: Otwinowski Z]]
[[Category: Pihlavisto M]]
[[Category: Salminen TA]]
[[Category: Smith DJ]]
[[Category: Szatmari I]]