View source for 4bqv


==MOUSE CATHEPSIN S WITH COVALENT LIGAND==
<StructureSection load='4bqv' size='340' side='right'caption='[[4bqv]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4bqv]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BQV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8PW:(2S,4R)-N-(1-CYANOCYCLOPROPYL)-1-(1-METHYLCYCLOPROPANECARBONYL)-4-[4-(2,2,2-TRIFLUOROETHOXY)-2-(TRIFLUOROMETHYL)PHENYL]SULFONYLPYRROLIDINE-2-CARBOXAMIDE'>8PW</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4bpv|4bpv]]</div></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bqv OCA], [https://pdbe.org/4bqv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bqv RCSB], [https://www.ebi.ac.uk/pdbsum/4bqv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bqv ProSAT]</span></td></tr>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/CATS_MOUSE CATS_MOUSE]] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N. 

==See Also==
*[[Cathepsin 3D structures|Cathepsin 3D structures]]
__TOC__
</StructureSection>
[[Category: Cathepsin S]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Banner, D W]]
[[Category: Benz, J]]
[[Category: Gsell, B]]
[[Category: Haap, W]]
[[Category: Ruf, A]]
[[Category: Stihle, M]]
[[Category: Cysteine protease]]
[[Category: Hydrolase]]