View source for 4bkp


==Crystal structure of human GDP-L-fucose synthase with bound NADP==
<StructureSection load='4bkp' size='340' side='right'caption='[[4bkp]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4bkp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BKP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BKP FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/GDP-L-fucose_synthase GDP-L-fucose synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.271 1.1.1.271] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bkp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bkp OCA], [https://pdbe.org/4bkp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bkp RCSB], [https://www.ebi.ac.uk/pdbsum/4bkp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bkp ProSAT]</span></td></tr>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/FCL_HUMAN FCL_HUMAN]] Two step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. 
__TOC__
</StructureSection>
[[Category: GDP-L-fucose synthase]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Bradley, A]]
[[Category: Delft, F von]]
[[Category: Edwards, A]]
[[Category: Kavanagh, K]]
[[Category: Krojer, T]]
[[Category: Oppermann, U]]
[[Category: Raynor, J W]]
[[Category: Rojkova, A]]
[[Category: Shafqat, N]]
[[Category: Vollmar, M]]
[[Category: Yue, W W]]
[[Category: Oxidoreductase]]