View source for 3zn5


==VP16, a capsid protein of bacteriophage P23-77 (VP16-virus-derived)==
<StructureSection load='3zn5' size='340' side='right'caption='[[3zn5]], [[Resolution|resolution]] 2.36&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3zn5]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZN5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZN5 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zmn|3zmn]], [[3zmo|3zmo]], [[3zn4|3zn4]], [[3zn6|3zn6]]</div></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zn5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zn5 OCA], [https://pdbe.org/3zn5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zn5 RCSB], [https://www.ebi.ac.uk/pdbsum/3zn5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zn5 ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
It has proved difficult to classify viruses unless they are closely related since their rapid evolution hinders detection of remote evolutionary relationships in their genetic sequences. However, structure varies more slowly than sequence, allowing deeper evolutionary relationships to be detected. Bacteriophage P23-77 is an example of a newly identified viral lineage, with members inhabiting extreme environments. We have solved multiple crystal structures of the major capsid proteins VP16 and VP17 of bacteriophage P23-77. They fit the 14 A resolution cryo-electron microscopy reconstruction of the entire virus exquisitely well, allowing us to propose a model for both the capsid architecture and viral assembly, quite different from previously published models. The structures of the capsid proteins and their mode of association to form the viral capsid suggest that the P23-77-like and adeno-PRD1 lineages of viruses share an extremely ancient common ancestor.

Bacteriophage p23-77 capsid protein structures reveal the archetype of an ancient branch from a major virus lineage.,Rissanen I, Grimes JM, Pawlowski A, Mantynen S, Harlos K, Bamford JK, Stuart DI Structure. 2013 May 7;21(5):718-26. doi: 10.1016/j.str.2013.02.026. Epub 2013 Apr, 25. PMID:23623731<ref>PMID:23623731</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 3zn5" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Bamford, J K.H]]
[[Category: Grimes, J M]]
[[Category: Harlos, K]]
[[Category: Mantynen, S]]
[[Category: Pawlowski, A]]
[[Category: Rissanen, I]]
[[Category: Stuart, D I]]
[[Category: Viral protein]]