View source for 3vbh


==Crystal structure of formaldehyde treated human enterovirus 71 (space group R32)==
<StructureSection load='3vbh' size='340' side='right'caption='[[3vbh]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3vbh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_enterovirus_71 Human enterovirus 71]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VBH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VBH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SPH:SPHINGOSINE'>SPH</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3vbf|3vbf]], [[3vbo|3vbo]], [[3vbr|3vbr]], [[3vbs|3vbs]], [[3vbu|3vbu]]</div></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vbh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vbh OCA], [https://pdbe.org/3vbh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vbh RCSB], [https://www.ebi.ac.uk/pdbsum/3vbh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vbh ProSAT]</span></td></tr>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/B2ZUN0_9ENTO B2ZUN0_9ENTO]] Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[SAAS:SAAS000199_004_016611]  Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266]  RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047] 
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== Publication Abstract from PubMed ==
Enterovirus 71 (EV71) is a major agent of hand, foot and mouth disease in children that can cause severe central nervous system disease and death. No vaccine or antiviral therapy is available. High-resolution structural analysis of the mature virus and natural empty particles shows that the mature virus is structurally similar to other enteroviruses. In contrast, the empty particles are markedly expanded and resemble elusive enterovirus-uncoating intermediates not previously characterized in atomic detail. Hydrophobic pockets in the EV71 capsid are collapsed in this expanded particle, providing a detailed explanation of the mechanism for receptor-binding triggered virus uncoating. These structures provide a model for enterovirus uncoating in which the VP1 GH loop acts as an adaptor-sensor for cellular receptor attachment, converting heterologous inputs to a generic uncoating mechanism, highlighting new opportunities for therapeutic intervention.

A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71.,Wang X, Peng W, Ren J, Hu Z, Xu J, Lou Z, Li X, Yin W, Shen X, Porta C, Walter TS, Evans G, Axford D, Owen R, Rowlands DJ, Wang J, Stuart DI, Fry EE, Rao Z Nat Struct Mol Biol. 2012 Mar 4. doi: 10.1038/nsmb.2255. PMID:22388738<ref>PMID:22388738</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 3vbh" style="background-color:#fffaf0;"></div>

==See Also==
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human enterovirus 71]]
[[Category: Large Structures]]
[[Category: Axford, D]]
[[Category: Evans, G]]
[[Category: Fry, E E]]
[[Category: Hu, Z]]
[[Category: Li, X]]
[[Category: Lou, Z]]
[[Category: Owen, R]]
[[Category: Peng, W]]
[[Category: Porta, C]]
[[Category: Rao, Z]]
[[Category: Ren, J]]
[[Category: Rowlands, D J]]
[[Category: Shen, X]]
[[Category: Stuart, D I]]
[[Category: Walter, T S]]
[[Category: Wang, J]]
[[Category: Wang, X]]
[[Category: Xu, J]]
[[Category: Yin, W]]
[[Category: Adaptor-sensor]]
[[Category: Enterovirus uncoating]]
[[Category: Hand-foot-and-mouth disease]]
[[Category: Icosahedral virus]]
[[Category: Pocket factor]]
[[Category: Virus]]