View source for 1fin

[[Image:1fin.gif|left|200px]]<br />
<applet load="1fin" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1fin, resolution 2.3&Aring;" />
'''CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX'''<br />

==Overview==
The crystal structure of the human cyclinA-cyclin-dependent kinase2, (CDK2)-ATP complex has been determined at 2.3 A resolution. CyclinA binds, to one side of CDK2's catalytic cleft, inducing large conformational, changes in its PSTAIRE helix and T-loop. These changes activate the kinase, by realigning active site residues and relieving the steric blockade at, the entrance of the catalytic cleft.

==About this Structure==
1FIN is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ATP as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1FIN OCA]. 

==Reference==
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex., Jeffrey PD, Russo AA, Polyak K, Gibbs E, Hurwitz J, Massague J, Pavletich NP, Nature. 1995 Jul 27;376(6538):313-20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7630397 7630397]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Jeffrey, P.D.]]
[[Category: Pavletich, N.P.]]
[[Category: Russo, A.A.]]
[[Category: ATP]]
[[Category: cdk]]
[[Category: complex (transferase/cyclin)]]
[[Category: cyclin]]
[[Category: phosphorylation]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:53:44 2007''