View source for 1fax

[[Image:1fax.gif|left|200px]]<br />
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'''COAGULATION FACTOR XA INHIBITOR COMPLEX'''<br />

==Overview==
The 3.0-A resolution x-ray structure of human des-Gla-coagulation factor, Xa (fXa) has been determined in complex with the synthetic inhibitor, DX-9065a. The binding geometry is characterized primarily by two, interaction sites: the naphthamidine group is fixed in the S1 pocket by a, typical salt bridge to Asp-189, while the pyrrolidine ring binds in the, unique aryl-binding site (S4) of fXa. Unlike the large majority of, inhibitor complexes with serine proteinases, Gly-216 (S3) does not, contribute to hydrogen bond formation. In contrast to typical thrombin, binding modes, the S2 site of fXa cannot be used by DX-9065a since it is, blocked by Tyr-99, and the aryl-binding site (S4) of fXa is lined by, carbonyl oxygen atoms that can accommodate positive charges. This has, implications for natural substrate recognition as well as for drug design.

==Disease==
Known disease associated with this structure: Factor X deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227600 227600]]

==About this Structure==
1FAX is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA and DX9 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] Structure known Active Site: CAT. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1FAX OCA]. 

==Reference==
X-ray structure of active site-inhibited clotting factor Xa. Implications for drug design and substrate recognition., Brandstetter H, Kuhne A, Bode W, Huber R, von der Saal W, Wirthensohn K, Engh RA, J Biol Chem. 1996 Nov 22;271(47):29988-92. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8939944 8939944]
[[Category: Coagulation factor Xa]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Brandstetter, H.]]
[[Category: Engh, R.A.]]
[[Category: CA]]
[[Category: DX9]]
[[Category: blood coagulation factor]]
[[Category: calcium-binding]]
[[Category: gamma-carboxyglutamic acid]]
[[Category: glycoprotein]]
[[Category: hydrolase]]
[[Category: plasma]]
[[Category: serine protease]]

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