View source for 3odx


==Crystal Structure of an N-terminally Truncated Linker-DH/PH Domains of p115-RhoGEF==
<StructureSection load='3odx' size='340' side='right'caption='[[3odx]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3odx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ODX FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3odo|3odo]], [[3odw|3odw]], [[1xcg|1xcg]], [[1x86|1x86]], [[3kz1|3kz1]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ARHGEF1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3odx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3odx OCA], [https://pdbe.org/3odx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3odx RCSB], [https://www.ebi.ac.uk/pdbsum/3odx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3odx ProSAT]</span></td></tr>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/ARHG1_HUMAN ARHG1_HUMAN]] Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.<ref>PMID:8810315</ref> <ref>PMID:9641915</ref> <ref>PMID:9641916</ref> <ref>PMID:20098430</ref>  

==See Also==
*[[Rho guanine nucleotide exchange factor 3D structures|Rho guanine nucleotide exchange factor 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Chen, Z]]
[[Category: Guo, L]]
[[Category: Sprang, S R]]
[[Category: Sternweis, P C]]
[[Category: Dh]]
[[Category: Ph]]
[[Category: Regulation of rhoa gtpase]]
[[Category: Rho]]
[[Category: Rhogef]]
[[Category: Signaling protein]]