View source for 7tz2


==Structure of human Fibrinogen-like protein 1==
<StructureSection load='7tz2' size='340' side='right'caption='[[7tz2]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7tz2]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TZ2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tz2 OCA], [https://pdbe.org/7tz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tz2 RCSB], [https://www.ebi.ac.uk/pdbsum/7tz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tz2 ProSAT]</span></td></tr>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/FGL1_HUMAN FGL1_HUMAN]] Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3 (PubMed:30580966). Responsible for LAG3 T-cell inhibitory function (PubMed:30580966). Binds LAG3 independently from MHC class II (MHC-II) (PubMed:30580966). Secreted by, and promotes growth of, hepatocytes (PubMed:11470158, PubMed:19880967).<ref>PMID:11470158</ref> <ref>PMID:19880967</ref> <ref>PMID:30580966</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Luca, V C]]
[[Category: Ming, Q]]
[[Category: Tran, T H]]
[[Category: Fibrinogen-like domain]]
[[Category: Immune suppression]]
[[Category: Immunosuppressant]]
[[Category: Oligomerization]]
[[Category: Secretion]]