View source for 3fw9


==Structure of berberine bridge enzyme in complex with (S)-scoulerine==
<StructureSection load='3fw9' size='340' side='right'caption='[[3fw9]], [[Resolution|resolution]] 1.49&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3fw9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/California_poppy California poppy]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FW9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FW9 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SLX:(13AS)-3,10-DIMETHOXY-5,8,13,13A-TETRAHYDRO-6H-ISOQUINO[3,2-A]ISOQUINOLINE-2,9-DIOL'>SLX</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3d2d|3d2d]], [[3d2h|3d2h]], [[3d2j|3d2j]], [[3fw7|3fw7]], [[3fw8|3fw8]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BBE1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3467 California poppy])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Reticuline_oxidase Reticuline oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.21.3.3 1.21.3.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fw9 OCA], [https://pdbe.org/3fw9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fw9 RCSB], [https://www.ebi.ac.uk/pdbsum/3fw9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fw9 ProSAT]</span></td></tr>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/RETO_ESCCA RETO_ESCCA]] Essential to the formation of benzophenanthridine alkaloids in the response of plants to pathogenic attack. Catalyzes the stereospecific conversion of the N-methyl moiety of (S)-reticuline into the berberine bridge carbon of (S)-scoulerine. 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fw/3fw9_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fw9 ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Reticuline oxidase|Reticuline oxidase]]
__TOC__
</StructureSection>
[[Category: California poppy]]
[[Category: Large Structures]]
[[Category: Reticuline oxidase]]
[[Category: Gruber, K]]
[[Category: Macheroux, P]]
[[Category: Winkler, A]]
[[Category: Alakloid biosynthesis]]
[[Category: Alkaloid metabolism]]
[[Category: Bi-covalent flavinylation]]
[[Category: Cytoplasmic vesicle]]
[[Category: Fad]]
[[Category: Flavoprotein]]
[[Category: Glycoprotein]]
[[Category: N-glycosylation]]
[[Category: Oxidoreductase]]