View source for 1jbj


==CD3 Epsilon and gamma Ectodomain Fragment Complex in Single-Chain Construct==
<StructureSection load='1jbj' size='340' side='right'caption='[[1jbj]], [[NMR_Ensembles_of_Models | 18 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1jbj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JBJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JBJ FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cd3e FOR EPSILON CHAIN/CD3G FOR GAMMA CHAIN ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jbj OCA], [https://pdbe.org/1jbj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jbj RCSB], [https://www.ebi.ac.uk/pdbsum/1jbj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jbj ProSAT]</span></td></tr>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/CD3E_MOUSE CD3E_MOUSE]] The CD3 complex mediates signal transduction. 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jb/1jbj_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jbj ConSurf].
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== Publication Abstract from PubMed ==
The T cell receptor (TCR) consists of genetically diverse disulfide-linked alpha and beta chains in noncovalent association with the invariant CD3 subunits. CD3 epsilon and CD3 gamma are integral components of both the TCR and pre-TCR. Here, we present the solution structure of a heterodimeric CD3 epsilon gamma ectodomain complex. A unique side-to-side hydrophobic interface between the two C2-set immunoglobulin-like domains and parallel pairing of their respective C-terminal beta strands are revealed. Mutational analysis confirms the importance of the distinctive linkage as well as the membrane proximal stalk motif (RxCxxCxE) for domain-domain association. These biochemical and structural analyses offer insights into the modular pairwise association of CD3 invariant chains. More importantly, the findings suggest how the rigidified CD3 elements participate in TCR-based signal transduction.

Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3 epsilon gamma heterodimer.,Sun ZJ, Kim KS, Wagner G, Reinherz EL Cell. 2001 Jun 29;105(7):913-23. PMID:11439187<ref>PMID:11439187</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1jbj" style="background-color:#fffaf0;"></div>

==See Also==
*[[CD3 3D structures|CD3 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Kim, K S]]
[[Category: Reinherz, E L]]
[[Category: Sun, Z Y.J]]
[[Category: Wagner, G]]
[[Category: Beta-sheet]]
[[Category: C2-set immunoglobulin superfamily]]
[[Category: H-bonded g strand pair]]
[[Category: Immune system]]
[[Category: Single-chain]]