View source for 3b84


==Crystal structure of the human BTB domain of the Krueppel related Zinc Finger Protein 3 (HKR3)==
<StructureSection load='3b84' size='340' side='right'caption='[[3b84]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3b84]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B84 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B84 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ZBTB48, HKR3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b84 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b84 OCA], [https://pdbe.org/3b84 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b84 RCSB], [https://www.ebi.ac.uk/pdbsum/3b84 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b84 ProSAT]</span></td></tr>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/ZBT48_HUMAN ZBT48_HUMAN]] Binds to and regulates the J and/or S elements in MHC II promoter.<ref>PMID:7969177</ref>  
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b8/3b84_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b84 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Bullock, A]]
[[Category: Cooper, C]]
[[Category: Delft, F von]]
[[Category: Edwards, A M]]
[[Category: Filippakopoulos, P]]
[[Category: Keates, T]]
[[Category: Knapp, S]]
[[Category: Pike, A C.W]]
[[Category: Pilka, E]]
[[Category: Structural genomic]]
[[Category: Salah, E]]
[[Category: Weigelt, J]]
[[Category: Activator]]
[[Category: Btb]]
[[Category: Dna-binding]]
[[Category: Hkr3]]
[[Category: Krueppel related zinc finger protein 3]]
[[Category: Metal-binding]]
[[Category: Nucleus]]
[[Category: Oncogene]]
[[Category: Sgc]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Zbtb48]]
[[Category: Zinc finger]]
[[Category: Zinc-finger]]