View source for 2yz8


==Crystal structure of the 32th Ig-like domain of human obscurin (KIAA1556)==
<StructureSection load='2yz8' size='340' side='right'caption='[[2yz8]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2yz8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YZ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YZ8 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2e7b|2e7b]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">OBSCN, KIAA1556 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yz8 OCA], [https://pdbe.org/2yz8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yz8 RCSB], [https://www.ebi.ac.uk/pdbsum/2yz8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yz8 ProSAT], [https://www.topsan.org/Proteins/RSGI/2yz8 TOPSAN]</span></td></tr>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/OBSCN_HUMAN OBSCN_HUMAN]] Involved in myofibrillogenesis. Seems to be involved in assembly of myosin into sarcomeric A bands in striated muscle. Isoform 3 together with ANK1 isoform Mu17/Ank1.5 may provide a molecular link between the sarcoplasmic reticulum and myofibrils.<ref>PMID:11448995</ref> <ref>PMID:16205939</ref>  
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yz/2yz8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yz8 ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Obscurin|Obscurin]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Chen, L]]
[[Category: Chrzas, J]]
[[Category: Fu, Z Q]]
[[Category: Kishishita, S]]
[[Category: Nishino, A]]
[[Category: Ohsawa, N]]
[[Category: Structural genomic]]
[[Category: Saijo, S]]
[[Category: Shirouzu, M]]
[[Category: Wang, B C]]
[[Category: Yokoyama, S]]
[[Category: Ig fold]]
[[Category: Kiaa1556]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Obsucurin]]
[[Category: Rsgi]]
[[Category: Structural protein]]
[[Category: Z-disk]]