View source for 2bai


==The Zinc finger domain of Mengovirus Leader polypeptide==
<StructureSection load='2bai' size='340' side='right'caption='[[2bai]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2bai]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enmgo Enmgo]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BAI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BAI FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bai OCA], [https://pdbe.org/2bai PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bai RCSB], [https://www.ebi.ac.uk/pdbsum/2bai PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bai ProSAT], [https://www.topsan.org/Proteins/CESG/2bai TOPSAN]</span></td></tr>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/POLG_ENMG3 POLG_ENMG3]] Capsid proteins VP1, VP2, VP3 and VP4 form a closed capsid enclosing the viral positive strand RNA genome. VP4 lies on the inner surface of the protein shell formed by VP1, VP2 and VP3. All the three latter proteins contain a beta-sheet structure called beta-barrel jelly roll. Together they form an icosahedral capsid (T=3) composed of 60 copies of each VP1, VP2, and VP3, with a diameter of approximately 300 Angstroms. VP1 is situated at the 12 fivefold axes, whereas VP2 and VP3 are located at the quasi-sixfold axes (By similarity).  Protein VP0: VP0 precursor is a component of immature procapsids (By similarity). 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ba/2bai_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bai ConSurf].
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== Publication Abstract from PubMed ==
The Leader protein is a defining feature of picornaviruses from the Cardiovirus genus. This protein was recently shown to inhibit cellular nucleocytoplasmic transport through an activity mapped to its zinc-binding region. Here we report the three-dimensional solution structure determined by nuclear magnetic resonance (NMR) spectroscopy of this domain (residues 5-28) from mengovirus. The domain forms a CHCC zinc-finger with a fold comprising a beta-hairpin followed by a short alpha-helix that can adopt two different conformations. This structure is divergent from those of other eukaryotic zinc-fingers and instead resembles motifs found in a group of DNA-binding proteins from Archaea.

NMR structure of the mengovirus Leader protein zinc-finger domain.,Cornilescu CC, Porter FW, Zhao KQ, Palmenberg AC, Markley JL FEBS Lett. 2008 Mar 19;582(6):896-900. Epub 2008 Feb 20. PMID:18291103<ref>PMID:18291103</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2bai" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Enmgo]]
[[Category: Large Structures]]
[[Category: Structural genomic]]
[[Category: Cornilescu, C C]]
[[Category: Lee, M S]]
[[Category: Markley, J L]]
[[Category: Palmenberg, A C]]
[[Category: Porter, F W]]
[[Category: Qin, Z]]
[[Category: Cardiovirus]]
[[Category: Cesg]]
[[Category: Mengovirus]]
[[Category: PSI, Protein structure initiative]]
[[Category: Viral protein]]
[[Category: Virus]]
[[Category: Viruse]]
[[Category: Zinc finger domain]]