View source for 2rd4


==Design of specific inhibitors of Phospholipase A2: Crystal structure of the complex of phospholipase A2 with pentapeptide Leu-Val-Phe-Phe-Ala at 2.9 A resolution==
<StructureSection load='2rd4' size='340' side='right'caption='[[2rd4]], [[Resolution|resolution]] 2.97&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2rd4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_sagittifera Naja sagittifera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RD4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RD4 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1s6b|1s6b]]</div></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rd4 OCA], [https://pdbe.org/2rd4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rd4 RCSB], [https://www.ebi.ac.uk/pdbsum/2rd4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rd4 ProSAT]</span></td></tr>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/PA2B1_NAJSG PA2B1_NAJSG]] PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. [[https://www.uniprot.org/uniprot/PA2A2_NAJSG PA2A2_NAJSG]] PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rd/2rd4_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rd4 ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Naja sagittifera]]
[[Category: Kaur, A]]
[[Category: Kaur, P]]
[[Category: Mirza, Z]]
[[Category: Sharma, S]]
[[Category: Singh, N]]
[[Category: Singh, T P]]
[[Category: Sinha, M]]
[[Category: Srinivasan, A]]
[[Category: Calcium]]
[[Category: Complex]]
[[Category: Hydrolase]]
[[Category: Lipid degradation]]
[[Category: Metal-binding]]
[[Category: Peptide inhibitor]]
[[Category: Phospholipase a2]]
[[Category: Secreted]]